刘玉胜，博士，教授，博士生导师
博士毕业于中科大，随后在中科院从事博士后研究，2022年加入东北林业大学，主要研究领域为“RNA转录后调控：Poly(A)尾巴和可变剪切的动态变化、功能和调控机制”，以第一或通讯作者在Nature Structural & Molecular Biology (2篇)，Nature Communications (2篇)，Nature Protocols，Science China-Life Sciences, iScience 等期刊上发表SCI 论文和著作10篇，授权国家专利2项并转化1项。
研究方向
开发新的多维度的单细胞高通量测序方法；探索哺乳动物母源-合子转变过程中表观动态变化规律、母源物质降解模式、合子基因激活机制等；拓展poly(A)尾巴的调控功能以及在mRNA基因治疗及mRNA疫苗中的应用。
代表性成果（# first authors; * corresponding authors）
1. Yusheng Liu#*, Wenrong Tao#, Shuang Wu#, Yiwei Zhang, Hu Nie, Zhenzhen Hou, Jingye Zhang, Zhen Yang, Zi-Jiang Chen, Jiaqiang Wang*, Falong Lu*, Keliang Wu*. Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes. Nature Communications, 2024, 15(1):5550.
2. Jiaqiang Wang*, Yiwei Zhang, Jiaze Gao, Guihai Feng, Chao Liu, Xueke Li, Pengcheng Li, Zhonghua Liu, Falong Lu, Leyun Wang*, Wei Li*, Qi Zhou*, Yusheng Liu*. Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos. Nature Structural & Molecular Biology, 2024, 31(9):1341-1354.
3. Yusheng Liu#, Keliang Wu#, Fanghong Shao#, Hu Nie, Jingye Zhang, Cheng Li, Zhenzhen Hou, Jiaqiang Wang*, Bing Zhou*, Han Zhao*, Falong Lu*. Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition. Nature Structural & Molecular Biology, 2023, 30(2): 200-215.
4. Shuang Wu, Yiwei Zhang, Lan Yao, Jiaqiang Wang*, Falong Lu*, and Yusheng Liu*. m(6)A-modified RNA possess distinct poly(A) tails. J Genet Genomics. 2022, 50(3):208-211.
5. Yusheng Liu#*, Hu Nie#, Yiwei Zhang#, Falong Lu*, Jiaqiang Wang*, Comprehensive analysis of mRNA poly(A) tails by PAIso-seq2, Science China-Life Sciences, 2022, 66(1): 187-190.
6. Yusheng Liu*, Yiwei Zhang, Jiaqiang Wang*, Falong Lu*. Transcriptome-wide measurement of poly(A) tail length and composition at sub-nanogram total RNA sensitivity by PAIso-seq. Nature Protocols, 2022, 17, 1980-2007.
7. Yusheng Liu, Hu Nie, Hongxiang Liu, Falong Lu*. Dynamic RNA 3' Uridylation and Guanylation during Mitosis. iScience, 2020. 23(8): p. 101402.
8. Yusheng Liu#, Hu Nie#, Hongxiang Liu, Falong Lu*. Poly(A) inclusive RNA isoform sequencing (PAIso-seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails. Nature Communications, 2019. 10(1): p. 5292.
9. Yusheng Liu#, Xukun Lu#, Junchao Shi, Xingjiang Yu, Xiaoxin Zhang, Kai Zhu, Zhaohong Yi, Enkui Duan, Lei Li*. BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis. Journal of Molecular Cell Biology, 2016, 8(4): 366-368.
10. Yusheng Liu*, Falong Lu*, Jiaqiang Wang*. Sequencing of Transcriptome-Wide Poly(A) Tails by PAIso-seq. Deadenylation: Methods and Protocols. Methods in Molecular Biology, 2024:2723:215-232(Book chapter).
科研项目
(1) 国自然，面上项目，在研，主持。
(2) 国自然，青年基金，在研，主持。
(3) 省基金，优秀青年，在研，主持。
(4) 中国博士后基金，特别资助，结题，主持。
(5) 中国博士后基金，面上项目，结题，主持。
专利
(1) 陆发隆; 刘玉胜, 一种待测样品中具有poly(A)尾巴的RNA的测序文库的构建方法, 2019-09-05, 中国, ZL201910837492.2 (已转化)
(2) 刘玉胜; 陆发隆, poly(A)尾巴非A修饰在促进mRNA翻译中的应用, 2024-1-23, 中国, ZL202210410067.7
招聘信息
1. 本实验室常年招收博士后。
2. 非常欢迎对生命科学或生物信息学有强烈好奇心且乐于动手的大一新生来实验室实习。
联系方式
E-mail：lys@nefu.edu.cn
电话：19969729912
地址：黑龙江省哈尔滨香坊区和兴路26号，东北林业大学生命科学学院（新逸夫教学楼）
